abstract：:The cell culture method was used to quantitatively evaluate the cytotoxicity to porcine corneal endothelial cells by drugs in the usual concentrations of intracameral injections (ICI). Time-dependent cytotoxicity of drugs was evaluated quantitatively; dye exclusion assay by trypan blue was used as a viability assay; a...

journal_title：Cornea

authors： Chang CH,Lin CP,Wang HZ

更新日期：1995-01-01 00:00:00

abstract：:Posterior polymorphous corneal dystrophy (PPD) is a rare bilateral, autosomal-dominant disease. The presence of the epitheliumlike endothelium and the thickening of Descemet's membrane by the posterior collagenous layer (PCL) has been reported in the majority of published cases. Reepithelialization of the posterior co...

journal_title：Cornea

authors： Sekundo W,Lee WR,Aitken DA,Kirkness CM

更新日期：1994-11-01 00:00:00

abstract：:Limbal allograft transplantation was performed consecutively in 16 eyes with thermal or chemical burns (n = 5), Terrien's degeneration (n = 2), congenital sclerocornea (n = 1), Stevens-Johnson syndrome (n = 1), and chronic keratoconjunctivitis (n = 7), by transplanting randomly selected cadaver limbocorneal grafts to ...

journal_title：Cornea

authors： Tsai RJ,Tseng SC

更新日期：1994-09-01 00:00:00

abstract：:Immunologic rejection is the main cause of corneal graft failure, especially in vascularized corneal beds. The purpose of this study was to investigate the effect of systemic Cyclosporine-A (CsA) on the survival of corneal allografts in heavily vascularized rabbit corneal beds, following alkali burn. Heavy corneal vas...

journal_title：Cornea

authors： Rehany U,Waisman M

更新日期：1994-09-01 00:00:00

abstract：:Primary graft failure is a rare but major complication of penetrating keratoplasty. An apparent clustering of four cases during a 1-month period led to a review of all 778 keratoplasties performed by nine surgeons at Massachusetts Eye and Ear Infirmary from July 1, 1986 to June 30, 1988. The objectives of this study w...

journal_title：Cornea

authors： Mead MD,Hyman L,Grimson R,Schein OD

更新日期：1994-07-01 00:00:00

abstract：:We present the case of a 47-year-old woman with bilateral iridocorneal endothelial syndrome. The iridocorneal endothelial syndrome has heretofore been considered a unilateral disorder. However, a review of the literature and examination of the patient presented in this report indicate that bilateral occurrence of the ...

journal_title：Cornea

authors： Hemady RK,Patel A,Blum S,Nirankari VS

更新日期：1994-07-01 00:00:00

abstract：:Eleven patients with severe corneal disease have been operated with a collar-button-shaped keratoprosthesis and have been followed for 9-36 months. Two of the devices have been removed, but the remainder are securely in place. Six of the patients have benefitted substantially in terms of improved vision. The complicat...

journal_title：Cornea

authors： Dohlman CH,Doane MG

更新日期：1994-05-01 00:00:00

abstract：:The authors describe the clinical, molecular genetic, and pathologic findings of a patient with corneal decompensation associated with the mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. Ultrastructurally abnormal mitochondria were observed and possibly implicate this organelle in the pathogenesis of corne...

journal_title：Cornea

authors： Chang TS,Johns DR,Stark WJ,Drachman DB,Green WR

更新日期：1994-05-01 00:00:00

abstract：:Penetrating keratoplasty is currently the only treatment for corneal endothelial dysfunction. Although corneal transplantation has a high success rate, a few problems still remain, such as the limited availability of donor grafts, the change in refraction after penetrating keratoplasty, and the higher chance of immune...

journal_title：Cornea

authors： Mohay J,Lange TM,Soltau JB,Wood TO,McLaughlin BJ

更新日期：1994-03-01 00:00:00

abstract：:Keratoconus is a progressive, noninflammatory, nonvascular axial corneal ectasia, with unclear etiology and pathogenesis. It has a prevalence of 50-230 per 100,000 and is a bilateral disorder in up to 90% of cases. The onset of keratoconus is usually at puberty and progresses over 10-20 years producing an irregular my...

journal_title：Cornea

authors： Bechrakis N,Blom ML,Stark WJ,Green WR

更新日期：1994-01-01 00:00:00

abstract：:Corneal epithelial permeability studies using fluorophotometers were performed on 90 eyes of 51 normal subjects. After recording the autofluorescence of the cornea (AFC) and of the lens (AFL), we applied 20 microliters of 2% sodium fluorescein to the conjunctival sac. The corneal fluorescence 45 min later (F45), which...

journal_title：Cornea

authors： Chang SW,Hu FR

更新日期：1993-11-01 00:00:00

abstract：:An evaluation of the final "sutures out" postoperative astigmatism in two groups of keratoconus patients undergoing penetrating keratoplasty is presented. Group I consists of a retrospective evaluation of keratoconus patients who underwent penetrating keratoplasty without using the Troutman Keratometer prior to suturi...

journal_title：Cornea

authors： Belmont SC,Troutman RC,Buzard KA

更新日期：1993-09-01 00:00:00

abstract：:This trial was a randomized, double-masked, crossover study during which patients with keratoconjunctivitis sicca underwent 6 weeks of treatment with either cyclosporine 1% ophthalmic ointment or placebo followed by 6 weeks of the alternative treatment. Washout periods using only unpreserved artificial tears preceded ...

journal_title：Cornea

authors： Laibovitz RA,Solch S,Andriano K,O'Connell M,Silverman MH

更新日期：1993-07-01 00:00:00

abstract：:Corneal neovascularization complicates many anterior segment diseases. Corneal laser photocoagulation using yellow light (577 nm) has been shown to reduce corneal neovascularization. No histopathologic studies of the effects of this treatment on the eye have been reported, however. Target (cornea) and nontarget (iris,...

journal_title：Cornea

authors： Hemady RK,Baer JC,Foster CS

更新日期：1993-05-01 00:00:00

abstract：:There recently have been several reports of microsporidial keratoconjunctivitis caused by the organism Encephalitozoon hellem. However, treatment of this infection has been largely ineffective. We report a case of a 35-year-old Hispanic woman with AIDS and E. hellem keratoconjunctivitis confirmed with light, electron,...

journal_title：Cornea

authors： Rosberger DF,Serdarevic ON,Erlandson RA,Bryan RT,Schwartz DA,Visvesvara GS,Keenan PC

更新日期：1993-05-01 00:00:00

abstract：:To compare the efficacy of ciprofloxacin hydrochloride ointment with that of ciprofloxacin drops for treatment of experimental Pseudomonas keratitis, rabbit eyes were infected by intrastromal injection of 10(3) colony-forming units (CFU) log-phase P. aeruginosa. Infected and uninfected eyes were treated with either 0....

journal_title：Cornea

authors： Hobden JA,O'Callaghan RJ,Insler MS,Hill JM

更新日期：1993-03-01 00:00:00

abstract：:Human type IV collagen discs were found to support proliferation and adhesion of rabbit corneal epithelial cells in tissue culture. To assess the biocompatibility of this synthetic collagen for epikeratoplasty, seven eyes of seven rhesus monkeys underwent epikeratoplasty with lenticules made of human type IV collagen....

journal_title：Cornea

authors： Thompson KP,Hanna KD,Gipson IK,Gravagna P,Waring GO 3rd,Johnson-Wint B

更新日期：1993-01-01 00:00:00

abstract：:Mycobacterium fortuitum keratitis is an indolent infection of traumatized corneas in humans. To study this disorder in an animal model, 10(4) M fortuitum organisms (10 microliters) were inoculated into the stroma of both corneas of 16 New Zealand albino rabbits. Eight of the rabbits were also given bilateral subconjun...

journal_title：Cornea

authors： Paschal JF,Holland GN,Sison RF,Berlin OG,Bruckner DA,Dugel PU,Foos RY

更新日期：1992-11-01 00:00:00

abstract：:The action of hydrogen peroxide on soluble proteins of the rat cornea has been evaluated. Two major corneal proteins are found to be oxidized by 10 mM hydrogen peroxide. Protein sequence and antibody recognition has shown one of the proteins to be albumin. Treatment of pure rat or human albumin with hydrogen peroxide ...

journal_title：Cornea

authors： Zhu L,Crouch RK

更新日期：1992-11-01 00:00:00

abstract：:An 81-year-old man with metastatic prostate carcinoma underwent a penetrating keratoplasty for phlyctenular keratitis. Two years later he developed a fleshy, vascular mass in the superotemporal corneal graft wound, at the site of prior graft sutures. An excisional biopsy of the mass was performed to rule out metastati...

journal_title：Cornea

authors： De Potter P,Tardio DJ,Shields CL,Shields JA

更新日期：1992-11-01 00:00:00

abstract：:We examined the effects of the immunotoxin 454A12-rRa on proliferating and confluent human corneal epithelium (HCE) in vitro. Proliferating HCE was sensitive to 454A12-rRA in a dose-dependent fashion. At immunotoxin concentrations of 1,000 ng/ml for 7 days we observed an 86% reduction in cell counts. Confluent HCE was...

journal_title：Cornea

authors： Fulcher SF,Foulks GN,Wilkerson M,Cobo LM,Jaffe GJ,Hatchell DL

更新日期：1992-09-01 00:00:00

abstract：:A randomized, double-blind, placebo-controlled, multicenter clinical trial was conducted in five centers to assess safety, ocular tolerance, and efficacy of an ophthalmic solution of epidermal growth factor (EGF) for the treatment of traumatic corneal epithelial defects. One hundred four patients completed the study: ...

journal_title：Cornea

authors： Pastor JC,Calonge M

更新日期：1992-07-01 00:00:00

abstract：:We evaluated the systemic absorption of ofloxacin eyedrops in humans and their availability in the tear film. Serum, urine, and tear film concentrations of ofloxacin were measured in 30 healthy women topically treated with 0.3% ofloxacin, in both eyes, four times daily for 10 1/2 days. Serum was collected before the f...

journal_title：Cornea

authors： Borrmann L,Tang-Liu DD,Kann J,Nista J,Lin ET,Frank J

更新日期：1992-05-01 00:00:00

abstract：:Posterior amorphous corneal dystrophy (PACD) is a rare autosomal-dominant disease, generally classified with the pre-Descemet's dystrophies. It is characterized by deep stromal corneal opacification, flat corneas with low keratometry values, and central thinning. To our knowledge, only one previous ultrastructural stu...

journal_title：Cornea

authors： Roth SI,Mittelman D,Stock EL

更新日期：1992-03-01 00:00:00

abstract：:We report a case of a patient with Down's syndrome and keratoconus with acute hydrops who was incidentally noted to have Axenfeld's anomaly. We also review the systemic abnormalities associated with Axenfeld's anomaly and the implications of the diagnosis. To our knowledge, Axenfeld's anomaly has not previously been r...

journal_title：Cornea

authors： Stokes DW,Parrish CM

更新日期：1992-03-01 00:00:00

abstract：:Two cases of intracorneal hemorrhage developing as a complication of aphakic contact lens use are reported. Patient 1 had a penetrating keratoplasty to restore vision and therefore the histologic examination could be performed on the corneal button. In patient 2 the contact lens use was discontinued with partial resol...

journal_title：Cornea

authors： al-Hussaini AK,Friedlander MH,Karcioglu ZA

更新日期：1992-01-01 00:00:00

abstract：:Absorbable intracanalicular collagen implants were placed in both canaliculi of one eye of nine human volunteers. The other eye served as a control. Twenty-four hours later 2% sodium fluorescein was placed into both conjunctival sacs. Serial corneal fluorescein concentrations were measured with a scanning ocular fluor...

journal_title：Cornea

authors： Unterman SR,Reidy JJ,Hill JH,Kaufman HE

更新日期：1991-11-01 00:00:00

abstract：:Utilizing transmission electron microscopy, the authors describe results obtained from cellulose acetate impressions of the bulbar conjunctiva in acquired immunodeficiency syndrome patients with cytomegalovirus (CMV) retinitis. Particles consistent with a retrovirus were isolated, but no CMV particles were demonstrate...

journal_title：Cornea

authors： Pastor SA,Shuster AR,Miller MM,Lam KW

更新日期：1991-11-01 00:00:00

abstract：:The pharmacokinetics and toxicity of subconjunctival (S/C) amphotericin B (AmB) were evaluated in Dutch-belted rabbits. Following the S/C injection of 1,500 micrograms of AmB, corneal and aqueous levels were determined by bioassay. The highest levels were present in the periphery of debrided corneas at 1 h (90.12 +/- ...

journal_title：Cornea

authors： O'Day DM,Smith R,Stevens JB,Williams TE,Robinson RD,Head WS

更新日期：1991-09-01 00:00:00

abstract：:Here we report a new method for image analysis of the corneal stroma. To obtain the biometric characteristics of a given area, we perform three different treatments of the same image. These automated predictions closely match each parameter (length, surface area, etc.), as measured manually by a "blind investigator." ...

journal_title：Cornea

authors： Karpouzas I,Durand JP,Keller N,Savoldelli M,Pouliquen Y

更新日期：1991-07-01 00:00:00

abstract：:The iridocorneal endothelial (ICE) syndrome is potentially a blinding condition as a result of glaucoma and/or corneal decompensation. The basic pathology seems to be in the corneal endothelium, which many studies confirm takes on a characteristic slit lamp appearance of hammered silver and image reversal with the spe...

journal_title：Cornea

authors： Sherrard ES,Frangoulis MA,Muir MG

更新日期：1991-05-01 00:00:00

abstract：:Persistent donor corneal epithelial defects following penetrating keratoplasty may lead to graft failure. We herein describe a method for providing corneal protection using a temporary suture tarsorrhaphy. This technique is simple and completely reversible, and it allows continued observation and instillation of topic...

journal_title：Cornea

authors： Koenig SB,Harris GJ

更新日期：1991-03-01 00:00:00

abstract：:We examined the surface epithelium of 30 eyes with color specular microscopy at 3-month intervals 1-18 months following penetrating keratoplasty. At least three examinations were performed on most eyes. We found a vortex keratopathy to be present in 70% of these eyes. In nine eyes, this vortex pattern was present at e...

journal_title：Cornea

authors： Mathers WD,Lemp MA

更新日期：1991-03-01 00:00:00

abstract：:The histological and ultrastructural pathology of two corneas that were removed from an infant with congenital glaucoma prior to keratoplasty is described. Clinically, the glaucoma was suspected to be due to an inapparent congenital viral infection, although there was no serological proof. Macroscopic and light micros...

journal_title：Cornea

authors： Löffler KU

更新日期：1991-01-01 00:00:00

abstract：:Penetrating keratoplasty (PKP) in conjunction with postoperative corticosteroids may reactivate latent herpes simplex virus type 1 (HSV-1) to cause persistent postoperative epithelial defects. The clinical diagnosis of HSV keratitis after penetrating keratoplasty is difficult because the postoperative appearance may b...

journal_title：Cornea

authors： Portnoy SL,Beyer CF,Hill JM,Kaufman HE

更新日期：1991-01-01 00:00:00

abstract：:In order to evaluate the effect of a commonly used sodium hyaluronate preparation (Healon, Pharmacia AB, Uppsala, Sweden) on the incidence of endothelial rejection, endothelial cell loss, intraocular pressure, and corneal thickness after penetrating keratoplasty, we conducted a randomized clinical trial. Patients were...

journal_title：Cornea

authors： Musch DC,Meyer RF,Sugar A,Soong HK

更新日期：1990-10-01 00:00:00

abstract：:We retrospectively examined Michigan Eye-Bank and Transplantation Center data on all eye/cornea donors in Michigan and Illinois for whom human immunodeficiency virus (HIV) antibody screening results were available. This was done to compare the HIV-antibody positive serology rate in hospital versus medical examiner don...

journal_title：Cornea

authors： Danneffel MB,Sugar A

更新日期：1990-07-01 00:00:00

abstract：:The present study describes biochemical and morphological differences of pseudophakic bullous keratopathy (PBK) corneas as compared with normal corneas. At the ultrastructural level, all PBK corneas studied had abnormal fibrillar material posterior to the Descemet's membrane. In addition, two of the six PBK buttons ha...

journal_title：Cornea

authors： Kenney MC,Chwa M

更新日期：1990-04-01 00:00:00

abstract：:Secondary corneal amyloidosis is a rare finding and only 17 cases have been reported in the literature. A case of unilateral secondary localized corneal amyloidosis is presented in a patient with bilateral interstitial keratitis and other stigmata of tertiary syphilis. ...

journal_title：Cornea

authors： Hill JC,Maske R,Bowen RM

更新日期：1990-04-01 00:00:00

abstract：:Contact lens (CL) fitting carries the risk of transmitting infectious agents, including adenovirus and Pseudomonas. Therefore, a number of precautions must be observed to ensure safety in the office. Paramount among these is hand washing, both immediately after contact with a patient's eyes and again between patients....

journal_title：Cornea

authors： Cohen EJ

更新日期：1990-01-01 00:00:00